Regulation of cardiomyocyte fate plasticity: a key strategy for cardiac regeneration
نویسندگان
چکیده
منابع مشابه
Features of cardiomyocyte proliferation and its potential for cardiac regeneration
The human heart does not regenerate. Instead, following injury, human hearts scar. The loss of contractile tissue contributes significantly to morbidity and mortality. In contrast to humans, zebrafish and newts faithfully regenerate their hearts. Interestingly, regeneration is in both cases based on cardiomyocyte proliferation. In addition, mammalian cardiomyocytes proliferate during foetal dev...
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Author for correspondence: Center for Regenerative Medicine in Barcelona, Dr. Aiguader, 88, 08003, Barcelona, Spain and Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 93027, USA Tel.: +1 858 453 4100 Fax: +1 858 453 2573 [email protected] [email protected] 20% of the ventricle. To directly identify the source of newly formed card...
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microRNAs are post-transcriptional regulators of gene expression that have been shown to be central players in the establishment of cellular programs, often acting as switches that control the choice between proliferation and differentiation during development and in adult tissues. The heart develops from two small patches of cells in the mesoderm, the heart fields, which originate the differen...
متن کاملTranscriptional reversion of cardiac myocyte fate during mammalian cardiac regeneration.
RATIONALE Neonatal mice have the capacity to regenerate their hearts in response to injury, but this potential is lost after the first week of life. The transcriptional changes that underpin mammalian cardiac regeneration have not been fully characterized at the molecular level. OBJECTIVE The objectives of our study were to determine whether myocytes revert the transcriptional phenotype to a ...
متن کاملCardiac regeneration based on mechanisms of cardiomyocyte proliferation and differentiation.
Cardiomyocyte proliferation and progenitor differentiation are endogenous mechanisms of myocardial development. Cardiomyocytes continue to proliferate in mammals for part of post-natal development. In adult mammals under homeostatic conditions, cardiomyocytes proliferate at an extremely low rate. Because the mechanisms of cardiomyocyte generation provide potential targets for stimulating myocar...
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ژورنال
عنوان ژورنال: Signal Transduction and Targeted Therapy
سال: 2021
ISSN: 2059-3635
DOI: 10.1038/s41392-020-00413-2